This study investigates a national sample of lesbian, gay, bisexual, queer and trans students to determine the association between mental health and microaggressions, victimization, psychological resilience, pride, and outness. Interpersonal microaggressions was a risk factor for depression and attempted suicide among cisgender LGBQ students, and was a risk factor for depression among trans students. Meanwhile, in all but one model, resilience was a protective factor which moderated the microaggressions-suicide relationship among cisgender LGBQ students. Pride moderated the victimization-depression relationship among trans students.